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GWAS Study

Genome wide association scan for chronic periodontitis implicates novel locus.

Feng P, Wang X, Casado PL et al.

25008200 PubMed ID
GWAS Study Type
2685 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

FP
Feng P
WX
Wang X
CP
Casado PL
KE
Küchler EC
DK
Deeley K
NJ
Noel J
KH
Kimm H
KJ
Kim JH
HA
Haas AN
QV
Quinelato V
BL
Bonato LL
GJ
Granjeiro JM
SC
Susin C
VA
Vieira AR
Chapter II

Abstract

Summary of the research findings

There is evidence for a genetic contribution to chronic periodontitis. In this study, we conducted a genome wide association study among 866 participants of the University of Pittsburgh Dental Registry and DNA Repository, whose periodontal diagnosis ranged from healthy (N = 767) to severe chronic periodontitis (N = 99).

63 European ancestry cases, 543 European ancestry controls, up to 32 African American cases, up to 158 African American controls, up to 4 cases, up to 66 controls

Chapter III

Study Statistics

Key metrics and study information

2685
Total Participants
GWAS
Study Type
Yes
Replicated
495 European ancestry cases, 981 European ancestry controls, 118 African ancestry cases, 225 African ancestry controls
Replication Participants
African American or Afro-Caribbean, European, Other, African unspecified
Ancestry
U.S., Brazil
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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