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GWAS Study

CKM and LILRB5 are associated with serum levels of creatine kinase.

Dubé MP, Zetler R, Barhdadi A et al.

25214527 PubMed ID
GWAS Study Type
6801 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

DM
Dubé MP
ZR
Zetler R
BA
Barhdadi A
BA
Brown AM
MI
Mongrain I
NV
Normand V
LN
Laplante N
AG
Asselin G
ZY
Zada YF
PS
Provost S
BJ
Bergeron J
KS
Kouz S
DR
Dufour R
DA
Diaz A
DD
de Denus S
TJ
Turgeon J
RE
Rhéaume E
PM
Phillips MS
TJ
Tardif JC
Chapter II

Abstract

Summary of the research findings

Statins (HMG-CoA reductase inhibitors) are the most prescribed class of lipid-lowering drugs for the treatment and prevention of cardiovascular disease. Creatine kinase (CK) is a commonly used biomarker to assist in the diagnosis of statin-induced myotoxicity but the normal range of CK concentrations is wide, which limits its use as a diagnostic biomarker.

3,412 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

6801
Total Participants
GWAS
Study Type
Yes
Replicated
3,389 European ancestry individuals
Replication Participants
European
Ancestry
Canada
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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