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GWAS Study

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

Rautanen A, Mills TC, Gordon AC et al.

25533491 PubMed ID
GWAS Study Type
2091 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

RA
Rautanen A
MT
Mills TC
GA
Gordon AC
HP
Hutton P
SM
Steffens M
NR
Nuamah R
CJ
Chiche JD
PT
Parks T
CS
Chapman SJ
DE
Davenport EE
EK
Elliott KS
BJ
Bion J
LP
Lichtner P
MT
Meitinger T
WT
Wienker TF
CM
Caulfield MJ
MC
Mein C
BF
Bloos F
BI
Bobek I
CP
Cotogni P
SV
Sramek V
SS
Sarapuu S
KM
Kobilay M
RV
Ranieri VM
RJ
Rello J
SG
Sirgo G
WY
Weiss YG
RS
Russwurm S
SE
Schneider EM
RK
Reinhart K
HP
Holloway PA
KJ
Knight JC
GC
Garrard CS
RJ
Russell JA
WK
Walley KR
SF
Stüber F
HA
Hill AV
HC
Hinds CJ
Chapter II

Abstract

Summary of the research findings

Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival.

359 European ancestry non-survivor cases, 1,194 European ancestry survivor cases

Chapter III

Study Statistics

Key metrics and study information

2091
Total Participants
GWAS
Study Type
Yes
Replicated
106 European ancestry non-survivor cases, 432 European ancestry survivor cases
Replication Participants
European
Ancestry
U.K.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.