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GWAS Study

A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.

Hirano A, Ohara T, Takahashi A et al.

26049409 PubMed ID
GWAS Study Type
17031 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HA
Hirano A
OT
Ohara T
TA
Takahashi A
AM
Aoki M
FY
Fuyuno Y
AK
Ashikawa K
MT
Morihara T
TM
Takeda M
KK
Kamino K
OE
Oshima E
OY
Okahisa Y
SN
Shibata N
AH
Arai H
AH
Akatsu H
IM
Ikeda M
IN
Iwata N
NT
Ninomiya T
MA
Monji A
KT
Kitazono T
KY
Kiyohara Y
KM
Kubo M
KS
Kanba S
Chapter II

Abstract

Summary of the research findings

Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations.

489 Japanese ancestry APOE-ε4 noncarrier cases, 6,463 Japanese ancestry APOE-ε4 noncarrier controls, 323 Japanese ancestry APOE-ε4 carrier cases, 1,484 Japanese ancestry APOE-ε4 carrier controls, 4 Japanese ancestry cases, 45 Japanese ancestry controls

Chapter III

Study Statistics

Key metrics and study information

17031
Total Participants
GWAS
Study Type
Yes
Replicated
528 Japanese ancestry APOE-ε4 noncarrier cases, 5,824 Japanese ancestry APOE-ε4 noncarrier controls, 480 Japanese ancestry APOE-ε4 carrier cases, 1,364 Japanese ancestry APOE-ε4 carrier controls, 3 Japanese ancestry cases, 24 Japanese ancestry controls
Replication Participants
East Asian
Ancestry
Japan
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.