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GWAS Study

High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.

Rivera NV, Ronninger M, Shchetynsky K et al.

26651848 PubMed ID
GWAS Study Type
9914 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

RN
Rivera NV
RM
Ronninger M
SK
Shchetynsky K
FA
Franke A
NM
Nöthen MM
MJ
Müller-Quernheim J
SS
Schreiber S
AI
Adrianto I
KB
Karakaya B
VM
van Moorsel CH
NZ
Navratilova Z
KV
Kolek V
RB
Rybicki BA
IM
Iannuzzi MC
PM
Petrek M
GJ
Grutters JC
MC
Montgomery C
FA
Fischer A
EA
Eklund A
PL
Padyukov L
GJ
Grunewald J
Chapter II

Abstract

Summary of the research findings

Rationale: Sarcoidosis is a multisystem disease of unknown cause. Löfgren's syndrome (LS) is a characteristic subgroup of sarcoidosis that is associated with a good prognosis in sarcoidosis. However, little is known about its genetic architecture or its broader phenotype, non-LS sarcoidosis.

568 Swedish ancestry cases, 2,025 Swedish ancestry controls

Chapter III

Study Statistics

Key metrics and study information

9914
Total Participants
GWAS
Study Type
Yes
Replicated
763 European ancestry cases, 4,901 European ancestry controls, 781 African American ancestry cases, 876 African American ancestry controls
Replication Participants
European, African American or Afro-Caribbean
Ancestry
Germany, Netherlands, Czech Republic, U.S., Sweden
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

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