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GWAS Study

CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

Wang X, Sun CL, Quiñones-Lombraña A et al.

26811534 PubMed ID
GWAS Study Type
385 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

WX
Wang X
SC
Sun CL
QA
Quiñones-Lombraña A
SP
Singh P
LW
Landier W
HL
Hageman L
MM
Mather M
RJ
Rotter JI
TK
Taylor KD
CY
Chen YD
AS
Armenian SH
WN
Winick N
GJ
Ginsberg JP
NJ
Neglia JP
OK
Oeffinger KC
CS
Castellino SM
DZ
Dreyer ZE
HM
Hudson MM
RL
Robison LL
BJ
Blanco JG
BS
Bhatia S
Chapter II

Abstract

Summary of the research findings

Purpose: Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could modify cardiomyopathy risk.

112 European ancestry cases, 219 European ancestry controls

Chapter III

Study Statistics

Key metrics and study information

385
Total Participants
GWAS
Study Type
Yes
Replicated
21 European ancestry cases, 12 Hispanic cases, 21 cases
Replication Participants
Other, European, Hispanic or Latin American
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.