HLA-C*01 is a Risk Factor for Crohn's Disease.
Jung ES, Cheon JH, Lee JH et al.
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Abstract
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A dysregulated mucosal immune response to the intestinal environment in a genetically susceptible host is hypothesized to be critical to the pathogenesis of Crohn's disease (CD). Therefore, we examined CD-susceptibility genes involved in the immune response through a genome-wide association study and consecutive genotyping of human leukocyte antigens (HLAs) and killer cell immunoglobulin-like receptors.
275 Korean ancestry cases, 2,369 Korean ancestry controls
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