A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants.
Bacchelli E, Cainazzo MM, Cameli C et al.
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Abstract
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Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been identified. The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms.
99 Italian ancestry cases, 359 Italian ancestry smoker controls
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