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GWAS Study

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population.

Carr DF, Bourgeois S, Chaponda M et al.

28062682 PubMed ID
GWAS Study Type
314 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CD
Carr DF
BS
Bourgeois S
CM
Chaponda M
TL
Takeshita LY
MA
Morris AP
CE
Castro EM
AA
Alfirevic A
JA
Jones AR
RD
Rigden DJ
HS
Haldenby S
KS
Khoo S
LD
Lalloo DG
HR
Heyderman RS
DC
Dandara C
KE
Kampira E
VO
van Oosterhout JJ
SF
Ssali F
MP
Munderi P
NG
Novelli G
BP
Borgiani P
NM
Nelson MR
HA
Holden A
DP
Deloukas P
PM
Pirmohamed M
Chapter II

Abstract

Summary of the research findings

The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

21 Sub-saharan African ancestry cases, 182 Sub-saharan African ancestry controls

Chapter III

Study Statistics

Key metrics and study information

314
Total Participants
GWAS
Study Type
Yes
Replicated
16 Sub-Saharan African ancestry cases, 27 African ancestry cases, 60 Sub-Saharan African ancestry controls, 8 African ancestry controls
Replication Participants
Sub-Saharan African, African unspecified
Ancestry
Malawi, Uganda, Mozambique
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

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