Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study.
Chittoor G, Haack K, Mehta NR et al.
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Abstract
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Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study.
768 Hispanic children from 260 families
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