Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
Terao C, Kawaguchi T, Dieude P et al.
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Abstract
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Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases.
700 Japanese ancestry cases, 1,797 Japanese ancestry controls, 564 European ancestry cases, 1,776 European ancestry controls
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