Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2.
Seyerle AA, Lin HJ, Gogarten SM et al.
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Abstract
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Objective: PR interval (PR) is a heritable electrocardiographic measure of atrial and atrioventricular nodal conduction. Changes in PR duration may be associated with atrial fibrillation, heart failure and all-cause mortality. Hispanic/Latino populations have high burdens of cardiovascular morbidity and mortality, are highly admixed and represent exceptional opportunities for novel locus identification. However, they remain chronically understudied. We present the first genome-wide association study (GWAS) of PR in 14 756 participants of Hispanic/Latino ancestry from three studies.
14,756 Hispanic individuals
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