Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.
Broce I, Karch CM, Wen N et al.
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Abstract
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Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk, a systematic investigation of genetic overlap between immune-mediated diseases and the spectrum of FTD-related disorders has not been performed.
2,154 frontotemporal dementia cases, 4,308 controls, 51,109 Crohn's disease cases and controls, 26,405 ulcerative colitis cases and controls, 25,708 rheumatoid arthritis cases and controls, 16,559 type 1 diabetes cases and controls,15,283 celiac disease cases and controls, 7,484 psoriasis cases and controls
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