Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.
Venkateswaran S, Prince J, Cutler DJ et al.
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Abstract
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The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84-1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59).
466 European ancestry cases, 2,099 European ancestry controls
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