Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.
Julià A, López-Longo FJ, Pérez Venegas JJ et al.
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Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disease heritability and additional risk variants have yet to be identified. Here we performed a GWAS followed by a meta-analysis to identify new genome-wide significant loci for SLE.
4,943 European ancestry cases, 8,483 European ancestry controls
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