Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
Nazarian A, Yashin AI, Kulminski AM
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Abstract
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Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance remains to be explained.
952 European ancestry male cases, 1,789 European ancestry female cases, 6,337 European ancestry male controls, 8,402 European ancestry female controls
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