Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.
Hoffman J, Fejerman L, Hu D et al.
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Abstract
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Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas.
2,385 Latina cases, 6,416 Latina controls
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