Multivariate analyses reveal biological components related to neuronal signaling and immunity mediating EEG abnormalities in alcohol-dependent individuals from the COGA cohort.
Meda SA, Narayanan B, Chorlian D et al.
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Abstract
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The underlying molecular mechanisms associated with alcohol use disorder (AUD) risk have only been partially revealed using traditional approaches such as univariate genomewide association and linkage-based analyses. We therefore aimed to identify gene clusters related to Electroencephalograms (EEG) neurobiological phenotypes distinctive to individuals with AUD using a multivariate approach.
432 European American cases, 367 European American controls
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