CORR® ORS Richard A. Brand Award: Disruption in Peroxisome Proliferator-Activated Receptor-γ (PPARG) Increases Osteonecrosis Risk Through Genetic Variance and Pharmacologic Modulation.
Wyles CC, Paradise CR, Houdek MT et al.
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Abstract
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The pathophysiology of osteonecrosis of the femoral head (ONFH) is poorly understood, and the diagnosis is idiopathic in as many as 40% of patients. Genetic and epigenetic etiologies have been postulated, yet no single nucleotide polymorphisms (SNPs) with intuitive biologic implications have been elucidated.
3 African American cases, 1 Asian ancestry case, 98 European ancestry cases, 6 African American controls, 1 Asian ancestry control, 4,118 European ancestry controls
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