The Promise of Selecting Individuals from the Extremes of Exposure in the Analysis of Gene-Physical Activity Interactions.
Osazuwa-Peters OL, Schwander K, Waken RJ et al.
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Abstract
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Dichotomization using the lower quartile as cutoff is commonly used for harmonizing heterogeneous physical activity (PA) measures across studies. However, this may create misclassification and hinder discovery of new loci.
1,913 European ancestry inactive individuals, 4,792 European ancestry active individuals
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