Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.
Adams MJ, Hill WD, Howard DM et al.
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Abstract
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People who opt to participate in scientific studies tend to be healthier, wealthier and more educated than the broader population. Although selection bias does not always pose a problem for analysing the relationships between exposures and diseases or other outcomes, it can lead to biased effect size estimates. Biased estimates may weaken the utility of genetic findings because the goal is often to make inferences in a new sample (such as in polygenic risk score analysis).
224,321 British ancestry cases, 147,096 British ancestry controls
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