Common and rare sequence variants influencing tumor biomarkers in blood.
Olafsson S, Alexandersson KF, Gizurarson JGK et al.
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Abstract
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Alpha-fetoprotein (AFP), cancer antigens 15.3, 19.9, and 125, carcinoembryonic antigen, and alkaline phosphatase (ALP) are widely measured in attempts to detect cancer and to monitor treatment response. However, due to lack of sensitivity and specificity, their utility is debated. The serum levels of these markers are affected by a number of nonmalignant factors, including genotype. Thus, it may be possible to improve both sensitivity and specificity by adjusting test results for genetic effects.
22,686 Icelandic ancestry individuals
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