Genetic modifiers of cystic fibrosis-related diabetes have extensive overlap with type 2 diabetes and related traits.
Aksit MA, Pace RG, Vecchio-Pagán B et al.
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Abstract
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Context: Individuals with cystic fibrosis (CF) develop a distinct form of diabetes characterized by β-cell dysfunction and islet amyloid accumulation similar to type 2 diabetes (T2D), but generally have normal insulin sensitivity. CF-related diabetes (CFRD) risk is determined by both CFTR, the gene responsible for CF, and other genetic variants.
1,341 European and unknown ancestry cases, 4,399 European and unknown ancestry controls
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