Genome-wide analysis identifies two susceptibility loci for positive thyroid peroxidase and thyroglobulin antibodies.
Matana A, Boutin T, Torlak V et al.
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Abstract
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Introduction: Thyroid peroxidase (TPO) and thyroglobulin (Tg) are main components of the thyroid gland and play an essential role in thyroid hormone synthesis. The development of antibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) is the major diagnostic hallmark and early indicator of autoimmune thyroid disease. TPOAb and TgAb are under strong genetic influence; however, genetic factors that determine thyroid antibody positivity are largely unknown.
619 Croatian ancestry cases, 1,994 Croatian ancestry controls
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