Region-based interaction detection in genome-wide case-control studies.
Zhang S, Jiang W, Ma RC et al.
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Abstract
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In genome-wide association study (GWAS), conventional interaction detection methods such as BOOST are mostly based on SNP-SNP interactions. Although single nucleotides are the building blocks of human genome, single nucleotide polymorphisms (SNPs) are not necessarily the smallest functional unit for complex phenotypes. Region-based strategies have been proved to be successful in studies aiming at marginal effects.
882 East Asian ancestry cases, 2,231 East Asian ancestry controls
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