Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders: A Genome-wide Association Study.
Bahrami S, Steen NE, Shadrin A et al.
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Abstract
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Importance: People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown.
at least 34,241 schizophrenia cases, 20,352 bipolar disorder cases, up to 135,458 major depression cases, 795,640 individuals with BMI measurements, 421,863 controls
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