Polygenic Hyperlipidemias and Coronary Artery Disease Risk.
Ripatti P, Rämö JT, Mars NJ et al.
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Abstract
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Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk.
324,708 British ancestry individuals
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