Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort.
Anstee QM, Darlay R, Cockell S et al.
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Abstract
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Background & aims: Genetic factors associated with non-alcoholic fatty liver disease (NAFLD) remain incompletely understood. To date, most genome-wide association studies (GWASs) have adopted radiologically assessed hepatic triglyceride content as the reference phenotype and so cannot address steatohepatitis or fibrosis. We describe a GWAS encompassing the full spectrum of histologically characterised NAFLD.
1,469 European ancestry individuals
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