Association between metformin medication, genetic variation and prostate cancer risk.
Lee MJ, Jayalath VH, Xu W et al.
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Abstract
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The relationship between metformin use and prostate cancer risk remains controversial. Genetic variation in metformin metabolism pathways appears to modify metformin glycemic control and the protective association with some cancers. However, no studies to date have examined this pharmacogenetic interaction and prostate cancer chemoprevention.
2,608 European ancestry individuals, 322 Asian ancestry individuals, 551 individuals
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