Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Russell AE, Ford T, Gunnell D et al.
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Abstract
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The causal role of inflammatory markers on self-harm and suicidal risk has been studied using observational data, with conflicting results. Confounding and reverse causation can lead to bias, so we appraised question from a genetic perspective to protect against these biases. We measured associations between genetic liability for high levels of inflammatory markers Interleukin-6 (IL-6) and C-reactive protein (CRP) on self-harm, and conducted a secondary analysis restricted to self-harm with suicidal intent.
3,470 European ancestry cases, 150,090 European ancestry controls
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