Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.
Lutz MW, Luo S, Williamson DE et al.
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Abstract
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Introduction: Late-onset Alzheimer's disease (LOAD) manifests comorbid neuropsychiatric symptoms and posttraumatic stress disorder (PTSD) is associated with an increased risk for dementia in late life, suggesting the two disorders may share genetic etiologies.
21,982 LOAD cases, 41,994 controls, 2,424 European ancestry PTSD cases, 7,113 European ancestry controls, 1,968 African American LOAD cases, 2,479 African American PTSD cases, 10,672 African American controls
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