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GWAS Study

Genome-wide association study of high-sensitivity C-reactive protein, D-dimer and Interleukin-6 levels in multi-ethnic HIV+ cohorts.

Sherman BT, Hu X, Singh K et al.

33095540 PubMed ID
GWAS Study Type
7052 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SB
Sherman BT
HX
Hu X
SK
Singh K
HL
Haine L
RA
Rupert AW
NJ
Neaton JD
LJ
Lundgren JD
IT
Imamichi T
CW
Chang W
LH
Lane HC
Chapter II

Abstract

Summary of the research findings

Objectives: Elevated levels of interleukin-6 (IL-6), D-dimer, and C-reactive protein (hsCRP) are associated with increased incidence of comorbid disease and mortality among people living with HIV (PLWH). Prior studies suggest a genetic basis for these biomarker elevations in the general population. The study objectives are to identify the genetic basis for these biomarkers among PLWH.

4,675 European ancestry individuals, 1,732 African ancestry individuals, 645 Admixed American individuals

Chapter III

Study Statistics

Key metrics and study information

7052
Total Participants
GWAS
Study Type
No
Replicated
European, African unspecified, Hispanic or Latin American
Ancestry
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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