A large-scale genome-wide association study meta-analysis of cannabis use disorder.
Johnson EC, Demontis D, Thorgeirsson TE et al.
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Abstract
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Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder.
17,068 European ancestry cases, 357,219 European ancestry controls, 3,848 African ancestry cases, 5,897 African ancestry controls
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