Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus.
Yin X, Kim K, Suetsugu H et al.
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Abstract
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Objective: Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations.
13,377 East Asian ancestry cases, 194,993 East Asian ancestry controls
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