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GWAS Study

Genome-wide association studies of exacerbations in children using long-acting beta2-agonists.

Slob EMA, Richards LB, Vijverberg SJH et al.

33706416 PubMed ID
GWAS Study Type
1425 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

SE
Slob EMA
RL
Richards LB
VS
Vijverberg SJH
LC
Longo C
KG
Koppelman GH
PM
Pijnenburg MWH
BE
Bel EHD
NA
Neerincx AH
HL
Herrera Luis E
PJ
Perez-Garcia J
TC
Tim Chew F
YS
Yie Sio Y
AA
Andiappan AK
TS
Turner SW
MS
Mukhopadhyay S
PC
Palmer CNA
HD
Hawcutt D
JA
Jorgensen AL
BE
Burchard EG
HN
Hernandez-Pacheco N
PM
Pino-Yanes M
MD
Maitland-van der Zee AH
Chapter II

Abstract

Summary of the research findings

Some children with asthma experience exacerbations despite long-acting beta2-agonist (LABA) treatment. While this variability is partly caused by genetic variation, no genome-wide study until now has investigated which genetic factors associated with risk of exacerbations despite LABA use in children with asthma. We aimed to assess whether genetic variation was associated with exacerbations in children treated with LABA from a global consortium.

642 European, Hispanic, African, Asian or unknown ancestry cases, 783 European, Hispanic, African, Asian or unknown ancestry controls

Chapter III

Study Statistics

Key metrics and study information

1425
Total Participants
GWAS
Study Type
No
Replicated
European, Hispanic or Latin American, African unspecified, Asian unspecified, NR, Other admixed ancestry
Ancestry
Netherlands, U.K., U.S., Singapore
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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Analysis In Progress

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