Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis.
Zhuang Z, Yao M, Wong JYY et al.
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Abstract
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Accumulating evidences have suggested that high body fat percentage (BF%) often occurs in parallel with cardiovascular diseases (CVDs), implying a common etiology between them. However, the shared genetic etiology underlying BF% and CVDs remains unclear.
89,297 European ancestry individuals with body fat percentage, 11,419 Korean ancestry, Indian ancestry, Jamaican ancestry individuals with body fat percentage, 61,289 European ancestry, East Asian ancestry, South Asian ancestry, African American, Hispanic cases with coronary artery disease, 134,524 European ancestry, East Asian ancestry, South Asian ancestry, African American, Hispanic controls without coronary artery disease
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