Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema.
Margaritte-Jeannin P, Budu-Aggrey A, Ege M et al.
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Abstract
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Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co-morbidity of two of these diseases, have not been considered. This may partly explain missing heritability.
1,208 European ancestry cases with both asthma and eczema, 7,599 European ancestry controls with neither asthma nor eczema
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