Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics.
Horimoto ARVR, Xue D, Thornton TA et al.
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Abstract
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Genetic studies have primarily been conducted in European ancestry populations, identifying dozens of loci associated with late-onset Alzheimer's disease (AD). However, much of AD's heritability remains unexplained; as the prevalence of AD varies across populations, the genetic architecture of the disease may also vary by population with the presence of novel variants or loci.
1,174 Caribbean Hispanics ancestry cases, 1,391 Caribbean Hispanics ancestry controls
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