Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.
Li Y, Bernstein CN, Xu W et al.
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Abstract
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Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluated the contribution of genetic variants to PC among the IBD population. Additionally, we evaluated whether this effect is mediated by the expression level of the RBPMS gene, which was identified in our previous studies as a potential risk factor of PC in persons with IBD.
94 European ancestry cases, 146 European ancestry controls
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