Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.
Vollert J, Wang R, Regis S et al.
Publication Details
Comprehensive information about this research publication
Abstract
Summary of the research findings
Irritable bowel syndrome (IBS) is a highly prevalent chronic pain disorder with multiple underlying mechanisms and few treatments that have been demonstrated to be effective in placebo controlled trials. One potential reason may be the use of composite outcomes, such as the IBS Symptom Severity Scale (IBS-SSS) which includes descriptive items related to pain frequency and pain intensity as well as bowel dysfunction and bloating. We investigated if different features of IBS pain have distinct genetic associations and if these may be moderated by sex hormones.
22 European ancestry double-blind peppermint oil-treated individuals, 53 European ancestry double-blind placebo-treated individuals, 52 European ancestry open-label placebo-treated individuals, 52 European ancestry no pill control-treated individuals, 4 double-blind peppermint oil-treated individuals, 9 double-blind placebo-treated individuals, 10 open-label placebo-treated individuals, 10 no pill control-treated individuals
Study Statistics
Key metrics and study information
Analysis
Comprehensive review of health and genetic findings
Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.
Analysis In Progress
Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.