A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility.
Sorosina M, Barizzone N, Clarelli F et al.
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Abstract
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Over 200 genetic loci have been associated with multiple sclerosis (MS) explaining ~ 50% of its heritability, suggesting that additional mechanisms may account for the "missing heritability" phenomenon.
1,701 Italian ancestry cases, 2,345 Italian ancestry controls
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