The Genetic Etiology of Periodic Leg Movement in Sleep.
Edelson JL, Schneider LD, Amar D et al.
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Abstract
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Study objectives: Periodic limb movement in sleep is a common sleep phenotype characterized by repetitive leg movements that occur during or before sleep. We conducted a genome-wide association study (GWAS) of periodic limb movements in sleep (PLMS) using a joint analysis (i.e., discovery, replication, and joint meta-analysis) of four cohorts (MrOS, the Wisconsin Sleep Cohort Study, HypnoLaus, and MESA), comprised of 6843 total subjects.
2,747 European, African, East Asian or Native American ancestry cases, 4,096 European, African, East Asian or Native American ancestry controls
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