A genome wide association study of chronic spontaneous urticaria risk and heterogeneity.
Chang D, Hammer C, Holweg CTJ et al.
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Abstract
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Chronic spontaneous urticaria (CSU) is a dermatologic condition characterized by spontaneous, pruritic hives and/or angioedema that persists for 6 weeks or longer with no identifiable trigger. Antihistamines and second-line therapies such as omalizumab are effective for some CSU patients, but others remain symptomatic, with significant impact on quality of life. This variable response to treatment and autoantibody levels across patients highlight clinically heterogeneous subgroups.
679 European ancestry, NR ancestry cases, 4,446 European ancestry, NR ancestry controls
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