Genome-wide imputation identifies novel associations and localises signals in idiopathic inflammatory myopathies.
Rothwell S, Amos CI, Miller FW et al.
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Abstract
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Objective: The idiopathic inflammatory myopathies (IIMs) are heterogeneous diseases thought to be initiated by immune activation in genetically predisposed individuals. We imputed variants from the ImmunoChip array using a large reference panel to fine-map associations and identify novel associations in IIM.
2,565 European ancestry cases, 10,260 European ancestry controls
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