Genome-Wide Association Study on Longitudinal Change in Fasting Plasma Glucose in Korean Population.
Jin H, Kwak SH, Yoon JW et al.
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Abstract
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Genome-wide association studies (GWAS) on type 2 diabetes mellitus (T2DM) have identified more than 400 distinct genetic loci associated with diabetes and nearly 120 loci for fasting plasma glucose (FPG) and fasting insulin level to date. However, genetic risk factors for the longitudinal deterioration of FPG have not been thoroughly evaluated. We aimed to identify genetic variants associated with longitudinal change of FPG over time.
1,027 East Asian ancestry cases, 9,501 East Asian ancestry controls
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