Multi-ancestry genome-wide association study of 4,069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A et al.
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Abstract
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Although recent sequencing studies have revealed that 10% of childhood gliomas are caused by rare germline mutations, the role of common variants is undetermined and no genome-wide significant risk loci for pediatric central nervous system tumors have been identified to date.
1,541 European ancestry cases, 7,183 European ancestry controls, 589 Hispanic or Latin American cases, 1,177 Hispanic or Latin American controls, 103 African American or Afro-Caribbean cases, 196 African American or Afro-Caribbean controls, 103 African ancestry cases, 196 African ancestry controls, 115 Asian ancestry cases, 222 Asian ancestry controls
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