Genome-Wide Analyses Characterize Shared Heritability Among Cancers and Identify Novel Cancer Susceptibility Regions.
Lindström S, Wang L, Feng H et al.
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Abstract
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The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.
122,977 European ancestry breast cancer cases, 55,168 European ancestry colorectal cancer cases, 12,906 European ancestry endometrial cancer cases, 4,112 European ancestry esophageal cancer cases, 12,488 European ancestry glioma cancer cases, 6,034 European ancestry head and neck cancer cases, 29,266 European ancestry lung cancer cases, 12,814 European ancestry melanoma cancer cases, 22,406 European ancestry ovarian cancer cases, 8,638 European ancestry pancreatic cancer cases, 79,166 European ancestry prostate cancer cases, 10,784 European ancestry renal cancer cases, 532,864 European ancestry controls
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