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GWAS Study

Genetic and non-genetic risk factors for early-onset pancreatic cancer.

Nodari Y, Gentiluomo M, Mohelnikova-Duchonova B et al.

36973108 PubMed ID
GWAS Study Type
11134 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

NY
Nodari Y
GM
Gentiluomo M
MB
Mohelnikova-Duchonova B
KE
Kreivenaite E
MA
Milanetto AC
SJ
Skieceviciene J
LS
Landi S
LR
Lawlor RT
PM
Petrone MC
AP
Arcidiacono PG
LM
Lovecek M
GM
Gazouli M
BM
Bijlsma MF
ML
Morelli L
KV
Kiudelis V
TM
Tacelli M
ZD
Zanette DL
SP
Soucek P
UF
Uzunoglu F
KR
Kaaks R
IJ
Izbicki J
BU
Boggi U
PR
Pezzilli R
MA
Mambrini A
PC
Pasquali C
VL
van Laarhoven HW
KV
Katzke V
CG
Cavestro GM
SC
Sperti C
LM
Loos M
LA
Latiano A
EB
Erőss B
OM
Oliverius M
JT
Johnson T
BD
Basso D
NJ
Neoptolemos JP
AM
Aoki MN
GW
Greenhalf W
VP
Vodicka P
AL
Archibugi L
VG
Vanella G
LM
Lucchesi M
TR
Talar-Wojnarowska R
JK
Jamroziak K
SM
Saeedi MA
VE
van Eijck CHJ
KJ
Kupcinskas J
HT
Hussein T
PM
Puzzono M
BS
Bunduc S
GM
Götz M
CS
Carrara S
SA
Szentesi A
TF
Tavano F
MS
Moz S
HP
Hegyi P
LC
Luchini C
CG
Capurso G
PF
Perri F
ES
Ermini S
TG
Theodoropoulos G
CG
Capretti G
PO
Palmieri O
GL
Ginocchi L
FN
Furbetta N
CF
Canzian F
CD
Campa D
Chapter II

Abstract

Summary of the research findings

Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC.

603 cases, 6,897 controls

Chapter III

Study Statistics

Key metrics and study information

11134
Total Participants
GWAS
Study Type
Yes
Replicated
309 European, East Asian, Hispanic/Latino or unknown ancestry cases, 3,325 European, East Asian, Hispanic/Latino or unknown ancestry controls
Replication Participants
European, NR, East Asian, Hispanic or Latin American
Ancestry
U.K., Lithuania, Germany, Greece, Netherlands, Czech Republic, Hungary, Japan, Ukraine, Denmark, Poland, Italy
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

Important Disclaimer: This review has been performed semi-automatically and is provided for informational purposes only. While we strive for accuracy, this analysis may contain errors, omissions, or misinterpretations of the original research. DNA Genics disclaims all liability for any inaccuracies, errors, or consequences arising from the use of this information. Users should independently verify all information and consult original research publications before making any decisions based on this content. This analysis is not intended as a substitute for professional scientific review or medical advice.

Analysis In Progress

Our analysis of this publication is currently being prepared. Please check back soon for comprehensive insights into the health and genetic findings discussed in this research.