Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.
Sofer T, Kurniansyah N, Murray M et al.
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Abstract
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Genome-wide association studies (GWAS) for obstructive sleep apnoea (OSA) are limited due to the underdiagnosis of OSA, leading to misclassification of OSA, which consequently reduces statistical power. We performed a GWAS of OSA in the Million Veteran Program (MVP) of the U.S. Department of Veterans Affairs (VA) healthcare system, where OSA prevalence is close to its true population prevalence.
23,651 black cases, 84,817 black controls, 1,720 Asian ancestry cases, 6,361 Asian ancestry controls, 117,496 European ancestry cases, 635,463 European ancestry controls, 11,056 Hispanic or Latin American cases, 34,840 Hispanic or Latin American controls, 130 cases, 1,162 controls
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