Identifying Genetic Loci and Phenomic Associations of Substance Use Traits: A Multi-trait Analysis of GWAS (MTAG) study.
Xu H, Toikumo S, Crist RC et al.
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Abstract
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Background and aims: Genome-wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sought to identify novel loci for substance use traits (SUTs) in both African- (AFR) and European- (EUR) ancestry individuals to enhance our understanding of the traits' genetic architecture.
74,635 European ancestry individuals (MTAG effective sample size boosted by cannabis use disorder, alcohol use disorder, smoking samples)
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